Sharpie is a permanent marker, so getting a Sharpie stain out is really difficult. First of all, HIDE all your Sharpie pens. I have mine in my top cupboard, so the kids can't reach them. But if the kids did get a hold of one, the best thing to do is try rubbing alcohol. It might spread the marking though, so be careful to dab and not rub around.
If you go to Sharpie.com, they also tell you what to do to remove a Sharpie stain. They list a product to use and they should know best. Here's what Sharpie says:
The successful stain removal of ink stains differs from case to case because of the many types of fabrics, colors, inks and time elapsed before stain removal. We cannot guarantee stain removal since many variables can be involved. Testing first is always recommended as well as following both the stain remover and clothing manufacturer's instructions. Following these steps should result in partial or complete removal.
General Rules:
1) Treat stains as soon as possible. Fresh stains can be removed more easily than old ones.
2) Check manufacturer's labels as to fabric content and any special instructions
3) Always test stain removal solution first on a hidden part of the article or on swatch of fabric taken from seam allowance to insure no color loss or damage will occur.
4) Where possible, lay stained article face down on paper towels or clean white cloth and apply stain removal solution to underside of stain so that stain can be removed from the surface instead of pushing it through the fabric. Replace towels or cloth as they absorb stain to prevent stain transfer.
5) If enlisting the aid of a professional laundry or dry cleaner, be sure to indicate what the stain is and the type of fabric.
6) Do not iron stained garments or put in dryer as this may set stain.
* Also try AMODEX STAIN REMOVER for permanent ink: http://www.amodexink.com/

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